Title of article :
Synthesis of Δ12,14-15-deoxy-PG-J1 methyl ester and epi-Δ12-15-deoxy-PG-J1
Author/Authors :
Mazhar Iqbal، نويسنده , , Yingfa Li، نويسنده , , Paul Evans، نويسنده ,
Issue Information :
هفته نامه با شماره پیاپی سال 2004
Abstract :
The synthesis of racemic Δ12,14-15-deoxy-PG-J1 is readily achieved in six steps employing as the key transformation a one-pot conjugate addition–Peterson olefination sequence using exo-2-trimethylsilyl-3a,4,7,7a-tetrahydro-4,7-methanoinden-1-one. Additionally a Noyori-type three-component coupling approach is employed for the synthesis of enantioenriched epi-Δ12-15-deoxy-PG-J1 from 4(S)-tert-butyldimethylsilyloxycyclopent-2-enone.
Keywords :
epi-?12-15-Deoxy-PG-J1 , Cross-conjugated cyclopenteone , ?12 , 14-15-Deoxy-PG-J1 methyl ester , Conjugate addition–Peterson olefination
Journal title :
Tetrahedron
Journal title :
Tetrahedron
