Author/Authors :
Panagiota Sofou، نويسنده , , Yiannis Elemes، نويسنده , , Eugenia Panou-Pomonis، نويسنده , , Athanassios Stavrakoudis، نويسنده , , Vassilios Tsikaris، نويسنده , , Constantinos Sakarellos، نويسنده , , Maria Sakarellos-Daitsiotis، نويسنده , , Michele Maggini، نويسنده , , Fernando Formaggio، نويسنده , , Claudio Toniolo، نويسنده ,
Abstract :
A proline-rich [60]fullerene peptide was synthesized by use of (i) a 1,3-dipolar cycloaddition of an N-substituted glycine derivative to [60]fullerene, (ii) esterification of the isolated alcohol with the C-terminal amino acid of the desired peptide sequence, and finally (iii) coupling of the remaining hexapeptide to give the final product as a TFA salt, with oxidized methionine. Product was found to be biologically active against sera from MCTD and SLE patients (ELISA experiment).
Keywords :
Fullerenes , 3-dipolar cycloadditions , Fullerene peptides , azomethine ylides , 1
