Title of article
Facile zeolite induced Fischer-indole synthesis: a new approach to bioactive natural product rutaecarpine
Author/Authors
Santosh B Mhaske، نويسنده , , Narshinha P Argade، نويسنده ,
Issue Information
هفته نامه با شماره پیاپی سال 2004
Pages
4
From page
3417
To page
3420
Abstract
Starting from glutaric anhydride () we have demonstrated an elegant six-step practical synthesis of bioactive natural product rutaecarpine () via o-amidoglutaranilic acid formation, esterification, chemoselective ester reduction, intramolecular dehydrative cyclizations, hydrazone formation and zeolite induced Fischer-indole synthesis with 53% overall yield. The conditions employed in the present synthesis are mild, efficient and general.
Keywords
Glutaric anhydride , Mackinazolinone , Rutaecarpine , Fischer indole synthesis , Zeolite
Journal title
Tetrahedron
Serial Year
2004
Journal title
Tetrahedron
Record number
1085266
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