Synthesis of new unsymmetrical polyarylester dendrimers

Preparation of polyarylester dendrimers containing 2-(hydroxymethyl)-1,4-butanediol and 2,2-bis(hydroxymethyl)-1,4-butanediol cores is described. These polyarylester dendrimers are unsymmetrical with respect to chain lengths and function as model systems for studying in vitro controlled drug release systems. Reaction conditions for deprotection of trichloroethyl group of the dendritic wedges have been improved.