Author/Authors :
Volkmar Wehner، نويسنده , , Hans Ulrich Stilz، نويسنده , , Sergej N Osipov، نويسنده , , Alexander M. Golubev، نويسنده , , Joachim Sieler، نويسنده , , Klaus Bürger، نويسنده ,
Abstract :
Preparatively simple, one-pot syntheses of trifluoromethyl-substituted hydantoins starting from Boc-protected imines of hexafluoroacetone and trifluoropyruvate are described. They represent valuable building blocks for the construction of constrained peptides or as scaffolds for the synthesis of highly potent VLA-4 antagonists.
