Application of palladium-catalyzed Pd–aryl/P–aryl exchanges: preparation of functionalized aryl phosphines by phosphination of aryl bromides using triarylphosphines

Palladium-catalyzed Pd–aryl/P–aryl interchange reaction was applied in the synthesis of various functionalized arylphosphines. This phosphination used inexpensive, readily available and air stable triarylphosphines as the phosphinating agents. Broad functional groups were compatible including keto, aldehyde, ester, nitrile, ether, chloride, pyridyl and thiophenyl groups. Halides were found to be good promoter for the rates and yields of the reaction.