Title of article :
Efficient synthesis of 2- and 3-substituted-2,3-dihydro [1,4]dioxino[2,3-b]pyridine derivatives
Author/Authors :
S Lazar، نويسنده , , M Soukri، نويسنده , , J.M. Leger، نويسنده , , C Jarry، نويسنده , , M Akssira، نويسنده , , R Chirita، نويسنده , , I.C Grig-Alexa، نويسنده , , A Finaru، نويسنده , , G Guillaumet، نويسنده ,
Abstract :
A versatile new approach for the synthesis in three steps of 2-substituted-2,3-dihydro[1,4]dioxino[2,3-b]pyridines via a Smiles rearrangement using easily available reagents is described. A study illustrating the influence of experimental conditions on the progress of the reaction is reported.
Keywords :
Smiles rearrangement , nucleophilic aromatic substitution , 2 , 3-b]pyridine
