Efficient route to 20–32 membered macrocyclic crown diamides via ring closing metathesis

RCM of the appropriate bis-allyloxyacetanilides and bis-o-allyloxyphenoxyacetanilides led to an efficient synthetic approach to the corresponding macrocylic polyoxadiamides with 20- to 32-membered ring sizes in good to excellent yields using Grubbsʹ catalyst.