Title of article :
Efficient solution phase parallel synthesis of norstatine analogs
Author/Authors :
Michael V. Voronkov، نويسنده , , Alexander V. Gontcharov، نويسنده , , Zhi-Min Wang، نويسنده , , Paul F. Richardson، نويسنده , , Hartmuth C. Kolb، نويسنده ,
Issue Information :
هفته نامه با شماره پیاپی سال 2004
Abstract :
The reaction of glycidic amides with various functionalized nitriles to afford norstatine analogs in a regio- and diastereoselective fashion (43–99% yield) is described. Utilizing this chemistry, a 20 membered solution phase library was prepared in two steps featuring three points of diversity.
Keywords :
Epoxide , Norstatine , nitrile , solution phase combinatorial chemistry
Journal title :
Tetrahedron
Journal title :
Tetrahedron
