Author/Authors :
Nageswara Rao Irlapati، نويسنده , , Robert M. Adlington، نويسنده , , Aurelia Conte، نويسنده , , Gareth J. Pritchard، نويسنده , , Rodolfo Marquez، نويسنده , , Jack E. Baldwin، نويسنده ,
Abstract :
The total synthesis of the naturally occurring kinase inhibitor pyridovericin is reported. A flexible and efficient synthesis has been accomplished in good yield from readily available 2,4-dihydroxypyridine. Pyridovericin is a key intermediate in our proposed biomimetic synthesis of pyridomacrolidin .
Keywords :
Pyridovericin , Pyridomacrolidin , Suzuki coupling , Metal–halogen exchange
