Title of article
Tubiferal A, a backbone-rearranged triterpenoid lactone isolated from the myxomycete Tubifera dimorphotheca, possessing reversal of drug resistance activity
Author/Authors
Kazuaki Kamata، نويسنده , , Hiroyuki Onuki، نويسنده , , Hiroshi Hirota، نويسنده , , Yukinori Yamamoto، نويسنده , , Masahiko Hayashi، نويسنده , , Kanki Komiyama، نويسنده , , Masaaki Sato، نويسنده , , Masami Ishibashi، نويسنده ,
Issue Information
هفته نامه با شماره پیاپی سال 2004
Pages
5
From page
9835
To page
9839
Abstract
Tubiferal A, a novel rearranged triterpenoid lactone, has been isolated from field-collected fruit bodies of the myxomycete, Tubifera dimorphotheca, and its structure elucidated by spectral data. Tubiferal A () possesses a 9,10-secocycloartan-16,21-olide skeleton, and this new compound exhibited a reversal effect of vincristine (VCR) resistance (more than 4-fold) against VCR-resistant KB cell lines. Tubiferal B (), corresponding to the seco acid of was also isolated, but showed no comparable activity.
Keywords
myxomycete , Tubifera dimorphotheca , Rearranged triterpenoid , Reveasal of drug resistance
Journal title
Tetrahedron
Serial Year
2004
Journal title
Tetrahedron
Record number
1087187
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