Efficient method for the synthesis of diphosphine ligands with a heteroaryl–aryl bridge

A new efficient method for the synthesis of heteroaryl–aryl diphosphine ligands by direct double metallation of heteroaryl–aryls followed by phosphorylation of the resulting o,o′-dilithium salts is described. A number of new C1-symmetric diphosphine ligands based on 3-arylheteroaryls, X-heteroaryls (X=N), and diphosphine ligands with a heterocyclic bridge with o-tolyl as the aryl fragment have been synthesized.