Novozym 435-catalyzed kinetic resolution of β-allenols. A facile route for the preparation of optically active β-allenols or allenyl acetates

A variety of optically active β-allenols and β-allenyl acetates were synthesized via the Novozym 435-mediated kinetic resolution of racemic β-allenols. A dramatic solvent effect was observed for the stereoselectivity. The scope of the substrates and the effect of the concentration and temperature on the reaction were also investigated.