Title of article
Selective methylphosphonylation of an echinocandin B analog derived from LY303366
Author/Authors
Uko E. Udodong، نويسنده , , Marvin M. Hansen، نويسنده , , Daniel E Verral، نويسنده , , Allen R. Harkness، نويسنده , , John L. Grutsch، نويسنده , , William D Miller، نويسنده , , Bret Astleford، نويسنده ,
Issue Information
هفته نامه با شماره پیاپی سال 2003
Pages
6
From page
2667
To page
2672
Abstract
Echinocandin B (ECB) analog was methylphosphonylated with the new reagent dimethyldiphosphonate . Selective functionalization of the phenol group was achieved in the presence of 11 other reactive alcohol and amide groups. The phosphonylation was best conducted in a mixture of THF and DMF using lithium t-butoxide as base. Methylphosphonate diester was deprotected by hydrogenolysis to afford methylphosphonate monoester , a potential prodrug for ECB analog .
Keywords
methylphosphonylation , echinocandin B , LY303366
Journal title
Tetrahedron
Serial Year
2003
Journal title
Tetrahedron
Record number
1087684
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