Title of article
Reaction of 2-substituted-4-oxo-4H-pyrido[1,2-a]pyrimidine-3-carbaldehyde oximes with electron-deficient olefins and acetylenes
Author/Authors
Masashi Shirai، نويسنده , , Hidekazu Kuwabara، نويسنده , , Masaya Nishiyama and Satoshi Matsumoto ، نويسنده , , Hidetoshi Yamamoto، نويسنده , , Akikazu Kakehi، نويسنده , , Michihiko Noguchi، نويسنده ,
Issue Information
هفته نامه با شماره پیاپی سال 2003
Pages
9
From page
4113
To page
4121
Abstract
A facile oxime–nitrone isomerization through the 1,2-hydrogen shift in 4-oxo-4H-pyrido[1,2-a]pyrimidine-3-carbaldehyde oximes is discussed. The resultant NH-nitrones are trapped by maleimides to afford intermolecular cycloadducts. The reaction of the oximes with electron-deficient acetylenes undergoes via another path initiated by a nucleophilic attack of the oxime to acetylene moiety.
Keywords
1 , Michael addition , oxime–nitrone isomerization , 3-dipolar cycloaddition
Journal title
Tetrahedron
Serial Year
2003
Journal title
Tetrahedron
Record number
1087831
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