Title of article
Biotransformation of triptolide by Cunninghamella blakesleana
Author/Authors
Lili Ning، نويسنده , , Jixun Zhan، نويسنده , , Guiqin Qu، نويسنده , , Lei Zhong، نويسنده , , Hongzhu Guo، نويسنده , , Kaishun Bi، نويسنده , , Dean Guo، نويسنده ,
Issue Information
هفته نامه با شماره پیاپی سال 2003
Pages
5
From page
4209
To page
4213
Abstract
Biotransformation of triptolide by Cunninghamella blakesleana (AS 3.970) was carried out. Seven biotransformation products were obtained and four of them were characterized as new compounds. On the basis of their NMR and mass spectral data, their structures were characterized as 5α-hydroxytriptolide , 1β-hydroxytriptolide , triptodiolide , 16-hydroxytriptolide , triptolidenol , 19α-hydroxytriptolide and 19β-hydroxytriptolide . All the new transformed products ( and ) were found to exhibit potent in vitro cytotoxicity against some human tumor cell lines.
Keywords
Biotransformation , Cunninghamella blakesleana , Triptolide
Journal title
Tetrahedron
Serial Year
2003
Journal title
Tetrahedron
Record number
1087842
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