Title of article
Chemoselective acylation of some oxidofunctionalised organolithium compounds
Author/Authors
Miguel Yus، نويسنده , , Joaqu??n Gomis، نويسنده ,
Issue Information
هفته نامه با شماره پیاپی سال 2003
Pages
5
From page
4967
To page
4971
Abstract
Once oxidofunctionalised organolithium compounds (easily prepared by reductive ring opening of isochroman and phthalan by DTBB-catalysed lithiation) were transmetallated with ZnBr2/CuCN·2LiCl and reacted successively with a carboxylic acid anhydride and an acyl chloride in THF at 0°C, the corresponding differently acylated compounds were obtained after hydrolysis with water. The anhydride performed the O-acylation exclusively and the acyl chloride carried out the C-acylation.
Keywords
lithiation , lithium and compounds , zinc and compounds , Catalysis , Acylation
Journal title
Tetrahedron
Serial Year
2003
Journal title
Tetrahedron
Record number
1087921
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