Calixarene amino acids; building blocks for calixarene peptides and peptide-dendrimers

A modular strategy towards receptor macromolecules is presented, which combines synthetically diverse peptide synthesis with highly functional calixarene chemistry. The design and synthesis of calix[4]arene amino acids , calix-lysines, is described, which were used as construction blocks to assemble nanoscale, multivalent entities—calix–peptides and calix–peptide-dendrimers .