Author/Authors :
Andrzej Frankowski، نويسنده , , Dariusz Deredas، نويسنده , , Estelle Dubost، نويسنده , , François Gessier، نويسنده , , Stefan Jankowski، نويسنده , , Markus Neuburger، نويسنده , , Czes?awa Seliga، نويسنده , , Theophile Tschamber، نويسنده , , Kamil Weinberg، نويسنده ,
Abstract :
The syntheses of imidazolo[1,5]hexopiperidinoses and imidazol-4(5)-yl C-glycosides are reported. The crucial step of this approach relies upon the SN2-type cyclisation of selectively protected C(1), C(2), C(3) and C(5)-substituted 1-[imidazol-4(5)-yl]pentitols in which the imidazole nitrogen or the C(1)-connected oxygen are involved as the competitive nucleophilic centers, respectively. Six selected imidazolosugars were evaluated as potential inhibitors of glycosidases.
