Title of article
Stereocontrolled synthesis of imidazolo[1,5]hexopiperidinoses and imidazol-4(5)-yl-C-glycosides
Author/Authors
Andrzej Frankowski، نويسنده , , Dariusz Deredas، نويسنده , , Estelle Dubost، نويسنده , , François Gessier، نويسنده , , Stefan Jankowski، نويسنده , , Markus Neuburger، نويسنده , , Czes?awa Seliga، نويسنده , , Theophile Tschamber، نويسنده , , Kamil Weinberg، نويسنده ,
Issue Information
هفته نامه با شماره پیاپی سال 2003
Pages
18
From page
6503
To page
6520
Abstract
The syntheses of imidazolo[1,5]hexopiperidinoses and imidazol-4(5)-yl C-glycosides are reported. The crucial step of this approach relies upon the SN2-type cyclisation of selectively protected C(1), C(2), C(3) and C(5)-substituted 1-[imidazol-4(5)-yl]pentitols in which the imidazole nitrogen or the C(1)-connected oxygen are involved as the competitive nucleophilic centers, respectively. Six selected imidazolosugars were evaluated as potential inhibitors of glycosidases.
Keywords
imidazolohexapiperidinoses , imidazolyl-C-glycosides , Glycosidase inhibition
Journal title
Tetrahedron
Serial Year
2003
Journal title
Tetrahedron
Record number
1088128
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