Title of article :
The trimethylsilyl xylyl (TIX) ether: a useful protecting group for alcohols
Author/Authors :
Ch Raji Reddy، نويسنده , , Amar G. Chittiboyina، نويسنده , , Rajashaker Kache، نويسنده , , Jae Chul Jung، نويسنده , , E. Blake Watkins، نويسنده , , Mitchell A. Avery، نويسنده ,
Issue Information :
هفته نامه با شماره پیاپی سال 2005
Abstract :
A new protecting group for alcohols, the p-trimethylsilyl xylyl (TIX) group has been developed. The TIX group is used to protect various alcohols under acidic as well as basic conditions. The protected ethers thus formed had noteworthy chemoselectivity upon deprotection in the presence of other benzyl ethers and commonly used protecting groups. The stability of the TIX group towards various reagents has also been examined.
Keywords :
Piperazino-piperidine nucleus , CCR5 antagonist , Reductive amination , Chiral pool , 4-Substituent-4-aminopiperidine
Journal title :
Tetrahedron
Journal title :
Tetrahedron
