Orthogonality and compatibility between Tsc and Fmoc amino-protecting groups

New deprotection conditions that provide a complete orthogonality between Tsc and Fmoc amino-protecting groups are described. The potential of these orthogonal deprotection conditions was then demonstrated by the efficient solid-phase synthesis of branched peptides and using doubly protected amino acids such as Tsc-Lys(Fmoc)-OH and Fmoc-Lys(Tsc)-OH .