Title of article
Asymmetric synthesis of aryloxypropanolamines via OsO4-catalyzed asymmetric dihydroxylation
Author/Authors
Iliyas A. Sayyed، نويسنده , , Vinay V. Thakur، نويسنده , , Milind D. Nikalje، نويسنده , , Gajanan K. Dewkar، نويسنده , , S.P. Kotkar، نويسنده , , A. Sudalai، نويسنده ,
Issue Information
هفته نامه با شماره پیاپی سال 2005
Pages
8
From page
2831
To page
2838
Abstract
A simple and effective procedure for the enantioselective synthesis of several β-adrenergic blocking agents incorporating the first asymmetric synthesis of celiprolol, is described. The key steps are (i) sharpless asymmetric dihydroxylation of aryl allyl ethers to introduce chirality into the molecules and (ii) conversion of cyclic sulfates into the corresponding epoxides using a three-step procedure.
Keywords
Asymmetric dihydroxylation , Epoxides , Antihypertensive , Cyclic sulfates
Journal title
Tetrahedron
Serial Year
2005
Journal title
Tetrahedron
Record number
1088511
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