Author/Authors :
April R. Banaag، نويسنده , , Gideon O. Berger، نويسنده , , Francis Dhoro، نويسنده , , Derrick B. delos Santos، نويسنده , , Darryl D. Dixon، نويسنده , , James P. Mitchell، نويسنده , , Bradley K. Tokeshi، نويسنده , , Marcus A. Tius، نويسنده ,
Abstract :
A general protocol for preparing densely functionalized cyclopentenones through a tandem nucleophilic addition–deprotonation–alkylation–cyclization process is described. Addition of lithioallene to enamides generates tetrahedral intermediate . Deprotonation of the γ carbon atom of the allene function in situ, followed by trapping by a suitable electrophile and cyclization during workup leads to C6 substituted cyclopentenones .
