Title of article :
On the reactivity of ascomycin at the binding domain. Part 3: Reactivity of the binding domain towards diazomethane
Author/Authors :
Karl Baumann، نويسنده , , Klemens Hoegenauer، نويسنده , , Hermann Knapp، نويسنده , , Markus Bacher، نويسنده , , Andrea Steck، نويسنده , , Trixie Wagner، نويسنده ,
Issue Information :
هفته نامه با شماره پیاپی سال 2005
Abstract :
A thorough product analysis of the reaction of ascomycin with diazomethane has been performed. Apart from the expected oxiranes (epimeric at C9), a whole range of novel derivatives bearing various modifications in the binding domain were obtained. Proposed mechanisms for their formation and stereochemical aspects are discussed.
Keywords :
ascomycin , Diazomethane , Methylene insertion , binding domain , X-ray analysis
Journal title :
Tetrahedron
Journal title :
Tetrahedron
