Conformationally restricted analogues of both (S)-β-homoserine and (S)-aspartic acid from chiral 3-acylamino pyrrolidin-2-ones

Starting from chiral 3,4-trans-disubstituted pyrrolidin-2-ones and , obtained from a Baylis–Hillman adduct, conformationally restricted analogues of both (S)-β-homoserine, , and (S)-aspartic acid, , were synthesized, respectively, and these compounds are suitable either for introduction in peptidomimetics or for synthesis of novel β-foldamers.