Title of article
Microwave mediated synthesis of spiro-(indoline-isoxazolidines): mechanistic study and biological activity evaluation
Author/Authors
Raunak، نويسنده , , Vineet Kumar، نويسنده , , Shubhasish Mukherjee، نويسنده , , Poonam، نويسنده , , Ashok K. Prasad، نويسنده , , Carl E. Olsen، نويسنده , , Susan J.C. Sch?ffer، نويسنده , , Sunil K. Sharma، نويسنده , , Arthur C. Watterson، نويسنده , , William Errington، نويسنده , , Virinder S. Parmar، نويسنده ,
Issue Information
هفته نامه با شماره پیاپی سال 2005
Pages
11
From page
5687
To page
5697
Abstract
Regioisomeric spiro-(indoline-isoxazolidines) have been synthesized in moderate yields by the cycloaddition reaction between ethyl (3-indolylidene)acetate and various substituted α,N-diphenylnitrones, using environmentally benign microwave technology. A novel concerted reaction mechanism is described that explains the preferential formation of the regioisomeric spiro-(indoline-isoxazolidine) analogs over . These compounds were screened for anti-mycobacterial and anti-invasive activities against tumor cells.
Keywords
Nitrone , cycloaddition reaction , Microwave , Spiro-(indoline-isoxazolidines) , Anti-invasive , Anti-mycobacterial
Journal title
Tetrahedron
Serial Year
2005
Journal title
Tetrahedron
Record number
1088785
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