Asymmetric synthesis of cytotoxic sponge metabolites R-strongylodiols A and B and an analogue

The asymmetric synthesis of the marine sponge natural products R-strongylodiols A and B , using a minimum protection strategy, is described. Two approaches were examined and the Noyori asymmetric reduction of ynones was found to be successful for installing the chirality of the natural products. Analogue was also prepared. In addition, asymmetric alkynylation of aldehydes is briefly reviewed.