Title of article
Asymmetric synthesis of cytotoxic sponge metabolites R-strongylodiols A and B and an analogue
Author/Authors
James E.D. Kirkham، نويسنده , , Timothy D.L. Courtney، نويسنده , , Victor Lee، نويسنده , , Jack E. Baldwin، نويسنده ,
Issue Information
هفته نامه با شماره پیاپی سال 2005
Pages
14
From page
7219
To page
7232
Abstract
The asymmetric synthesis of the marine sponge natural products R-strongylodiols A and B , using a minimum protection strategy, is described. Two approaches were examined and the Noyori asymmetric reduction of ynones was found to be successful for installing the chirality of the natural products. Analogue was also prepared. In addition, asymmetric alkynylation of aldehydes is briefly reviewed.
Keywords
Sponge , Zinc triflate , N-Methylephedrine , alkyne , asymmetric reduction
Journal title
Tetrahedron
Serial Year
2005
Journal title
Tetrahedron
Record number
1088942
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