Oligosaccharide synthesis on a soluble, hyperbranched polymer support via thioglycoside activation

The synthesis of linear and branched di-, tri- and tetramannosides on a commercially available hyperbranched polyester as a soluble, high loading support is described. Glycosylation products were isolated in 26–63% yield as mixtures of anomers after total hydrolytic degradation of the polymer. All polymer-bound intermediates were purified through simple extraction or precipitation. Solution-phase NMR and MALDI-TOF were used to monitor the progress of the reaction directly on the hyperbranched polymer support.