Title of article :
Solid-phase synthesis of 6-hydroxy-2,4-diaminoquinazolines
Author/Authors :
Csaba Wéber، نويسنده , , Attila Bielik، نويسنده , , ?d?m Demeter، نويسنده , , Istv?n Borza، نويسنده , , Gy?rgyi I. Szendrei، نويسنده , , Gy?rgy M. Keser?، نويسنده , , Istv?n Greiner، نويسنده ,
Issue Information :
هفته نامه با شماره پیاپی سال 2005
Abstract :
A new method for the solid-phase synthesis of 6-hydroxy-2,4-diaminoquinazolines has been developed. The synthesis utilizes solid-phase bound 6-hydroxy-2,4-dichloroquinazoline as a key intermediate. Sequential substitution of the two chlorines furnishes the title compounds regioselectively with high purity. A library of 18×22 compounds demonstrates the general utility of this approach.
Keywords :
quinazolines , NMDA , Amination , Library , Regioselectivity , Demethylation , Mitsunobu , Solid-phase synthesis
Journal title :
Tetrahedron
Journal title :
Tetrahedron
