Title of article
Solid-phase synthesis of 6-hydroxy-2,4-diaminoquinazolines
Author/Authors
Csaba Wéber، نويسنده , , Attila Bielik، نويسنده , , ?d?m Demeter، نويسنده , , Istv?n Borza، نويسنده , , Gy?rgyi I. Szendrei، نويسنده , , Gy?rgy M. Keser?، نويسنده , , Istv?n Greiner، نويسنده ,
Issue Information
هفته نامه با شماره پیاپی سال 2005
Pages
6
From page
9375
To page
9380
Abstract
A new method for the solid-phase synthesis of 6-hydroxy-2,4-diaminoquinazolines has been developed. The synthesis utilizes solid-phase bound 6-hydroxy-2,4-dichloroquinazoline as a key intermediate. Sequential substitution of the two chlorines furnishes the title compounds regioselectively with high purity. A library of 18×22 compounds demonstrates the general utility of this approach.
Keywords
quinazolines , NMDA , Amination , Library , Regioselectivity , Demethylation , Mitsunobu , Solid-phase synthesis
Journal title
Tetrahedron
Serial Year
2005
Journal title
Tetrahedron
Record number
1089166
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