Author/Authors :
Shukun Li، نويسنده , , Xiangshu Xiao، نويسنده , , Xuebin Yan، نويسنده , , Xuejun Liu، نويسنده , , Rui Xu، نويسنده , , Donglu Bai، نويسنده ,
Abstract :
A seco-precursor of macrolactin A was synthesized by coupling two advanced segments. Wittig reaction and Horner–Emmons reaction were utilized to construct the three characteristic E,Z and E,E dienes. The C1–C10 segment was synthesized through Horner–Emmons reaction with phosphonate reagent. The α-alkylation of sulfone stabilized anion with allyl bromide followed by desulfonation gave the C11–C24 segment.
