Title of article
Synthesis, structural determination and photo-antiproliferative activity of new 3-pyrazolyl or -isoxazolyl substituted 4-hydroxy-2(1H)-quinolinones
Author/Authors
Stefano Chimichi، نويسنده , , Marco Boccalini، نويسنده , , Mohamed M.M. Hassan، نويسنده , , Giampietro Viola، نويسنده , , Francesco DallʹAcqua، نويسنده , , Massimo Curini، نويسنده ,
Issue Information
هفته نامه با شماره پیاپی سال 2006
Pages
7
From page
90
To page
96
Abstract
A convenient route to new 3-quinolinonyl-pyrazoles and isoxazoles is described through cyclization of 3-[(E)-3-(dimethylamino)-2-propenoyl]-4-hydroxy-1-methyl-2(1H)-quinolinone. The phototoxicity as well as the cytotoxic activities of the title compounds are evaluated against leukemia- and adenocarcinoma-derived cell lines in comparison to the normal human keratinocytes.
Keywords
isoxazoles , 15N NMR , Antitumoral compounds , Pyrazoles , 4-Hydroxy-2(1H)-quinolinones , Structural determination
Journal title
Tetrahedron
Serial Year
2006
Journal title
Tetrahedron
Record number
1089471
Link To Document