New strategy towards the efficient solid phase synthesis of cyclopeptides

Synthetic cyclopeptides, and particularly those designed from VEGF structure, present considerable interest for the development of nanodevices devoted to tumor imaging or drug delivery. In order to obtain functionalizable cyclopeptides, we herein present a novel efficient way based on Fmoc-Lys-ODmab use, which was applied to the synthesis of c(PHGRIK) cyclopeptide.