Title of article :
Synthesis of trans-perhydroisoquinolines by 6-endo-trig radical cyclization of amino-tethered vinyl bromides and cyclohexenes
Author/Authors :
Josefina Quirante، نويسنده , , Xavier Vilà، نويسنده , , Laura Paloma، نويسنده , , Josep M. Guiu، نويسنده , , Josep Bonjoch، نويسنده ,
Issue Information :
هفته نامه با شماره پیاپی سال 2007
Abstract :
Bu3SnH-promoted cyclization of several N-(2-bromoprop-2-enyl)-N-[(4-oxocyclohex-1-enyl)methyl]alkylamines is reported. It has been found that the generated vinyl radicals evolve through a 6-endo-cyclization pathway giving rise to the corresponding 4,6-functionalized perhydroisoquinolines in a prevalent trans-relative configuration.
Keywords :
Nitrogen heterocycles , Radical cyclization , Decahydroisoquinolines , Vinyl radicals
Journal title :
Tetrahedron
Journal title :
Tetrahedron
