Title of article
New synthetic approach to atypical retinoids: application of a versatile annulation procedure
Author/Authors
Elisabetta Brenna، نويسنده , , Claudio Fuganti، نويسنده , , Giovanni Fronza، نويسنده , , Francesco G. Gatti، نويسنده , , Federico Sala، نويسنده , , Stefano Serra، نويسنده ,
Issue Information
هفته نامه با شماره پیاپی سال 2007
Pages
6
From page
2351
To page
2356
Abstract
A new approach to an atypical retinoid is presented. The C15 skeleton was built up by exploiting a step-by-step sequence: the C9 fragment of an intermediate was homologated by reaction with a C4 phosphorane, and then submitted to a benzannulation reaction. The last two carbon atoms were inserted by a Wittig reaction with the C2 phosphorane of ethyl bromoacetate. Manipulation of functional groups was then performed.
Keywords
Cancer therapy , Atypical retinoids , Benzene ring , annulation
Journal title
Tetrahedron
Serial Year
2007
Journal title
Tetrahedron
Record number
1090404
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