Title of article
Straightforward three-component synthesis of diarylmethylpiperazines and 1,2-diarylethylpiperazines
Author/Authors
Stéphane Sengmany، نويسنده , , Erwan Le Gall، نويسنده , , Cédric Le Jean، نويسنده , , Michel Troupel، نويسنده , , Jean Yves Nédelec، نويسنده ,
Issue Information
هفته نامه با شماره پیاپی سال 2007
Pages
10
From page
3672
To page
3681
Abstract
Several functionalized diarylmethylpiperazines and 1,2-diarylethylpiperazines have been synthesized in moderate to high yield according to a one-step three-component coupling between an aromatic or a benzylic organozinc reagent, a piperazine derivative, and an aromatic aldehyde. The procedure can be extended to the synthesis of benzylpiperazine derivatives or β-arylethylpiperazines toward the use of paraformaldehyde or aliphatic aldehydes.
Keywords
2-Diarylethylpiperazines , Arylzinc reagents , Three-component reaction , 1 , Diarylmethylpiperazines , Benzylzinc reagents
Journal title
Tetrahedron
Serial Year
2007
Journal title
Tetrahedron
Record number
1090638
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