Synthesis of symmetrical amino and aminomethyl derivatives of Trögerʹs base via Pd-catalyzed C–C and C–N bond formation

In this paper, we report the synthesis of amino and aminomethyl derivatives of Trögerʹs base (±)-1 and (±)-2. The key steps in the synthesis of (±)-1 and (±)-2 are Pd-catalyzed amination and cyanation, respectively, of the easily accessible dihalo derivatives (±)-3. These compounds are important intermediates in the synthesis of new ligands and building blocks for H-bonded supramolecular architectures.