Title of article
The combined use of stereoelectronic control and ring closing metathesis for the synthesis of (−)-8-epi-swainsonine
Author/Authors
Adrian J. Murray، نويسنده , , Philip J. Parsons، نويسنده , , Peter Hitchcock، نويسنده ,
Issue Information
هفته نامه با شماره پیاپی سال 2007
Pages
8
From page
6485
To page
6492
Abstract
A novel and efficient synthesis of (−)-8-epi-swainsonine 2 is reported. Stereocontrolled diol formation from the bicyclic alkene 3 followed by a stereoselective vinylation of the aldehyde and ring closing metathesis gave the indolizidine ring system, which was converted into (−)-8-epi-swainsonine 2.
Keywords
Stereoselective , Stereoelectronic , Indolizidine synthesis , Metathesis
Journal title
Tetrahedron
Serial Year
2007
Journal title
Tetrahedron
Record number
1091128
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