Title of article
Efficient method for the asymmetric reduction of α- and β-ketophosphonates
Author/Authors
V.V. Nesterov، نويسنده , , O.I. Kolodiazhnyi، نويسنده ,
Issue Information
هفته نامه با شماره پیاپی سال 2007
Pages
12
From page
6720
To page
6731
Abstract
An efficient and versatile method for the asymmetric reduction of α- and β-ketophosphonates using chiral reactant derived from sodium borohydride and l-(+)- or d-(−)-tartaric acid is developed. The methodology was used for the preparation of a number of biologically interesting enantiomerically pure products: including 2,3-epoxypropylphosphonate 11, 2-hydroxy-3-aminopropylphosphonic acid 14 (phospho-GABOB), phospho-carnitine 19, and others in multigram scale.
Keywords
Sodium borohydride/tartaric acid adduct , Double asymmetric induction , Phospho-carnitine , Phospho-GABOB , 2S , asymmetric reduction , Di(1R , 5R)-menthyl (S)-2-hydroxy-3-chloropropylphosphonate
Journal title
Tetrahedron
Serial Year
2007
Journal title
Tetrahedron
Record number
1091169
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