Title of article
Practical synthesis and applications of benzoboroxoles
Author/Authors
Dinara S. Gunasekera، نويسنده , , Dennis J. Gerold، نويسنده , , Nathan S. Aalderks، نويسنده , , J. Subash Chandra، نويسنده , , Christiana A. Maanu، نويسنده , , Paul Kiprof، نويسنده , , Viktor V. Zhdankin، نويسنده , , M. Venkat Ram Reddy، نويسنده ,
Issue Information
هفته نامه با شماره پیاپی سال 2007
Pages
5
From page
9401
To page
9405
Abstract
A convenient one-pot synthesis of benzoboroxoles has been developed via the reaction of o-bromobenzyl alcohols with NaH, nBuLi, and B(OiPr)3 followed by acidic hydrolysis. Applications of these benzoboroxoles have been demonstrated in Pd-catalyzed cross-coupling reactions and the protocol has been extended for the synthesis of a chiral benzoboroxole. Exceptionally short synthesis of a potent antifungal agent AN2690 and several of its analogs has also been realized.
Keywords
Boronic acids , Benzoboroxoles , C–C bond formation , Suzuki–Miyaura cross-coupling , Onychomycosis , Boronate esters
Journal title
Tetrahedron
Serial Year
2007
Journal title
Tetrahedron
Record number
1093195
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