Title of article
Synthesis and antiviral properties of aza-analogues of ganciclovir derived from 5,5-bis(hydroxymethyl)pyrrolidin-2-one
Author/Authors
Mariola Koszytkowska-Stawi?ska، نويسنده , , Ewa Ko?aczkowska، نويسنده , , Ewa Adamkiewicz، نويسنده , , Erik De Clercq، نويسنده ,
Issue Information
هفته نامه با شماره پیاپی سال 2007
Pages
9
From page
10587
To page
10595
Abstract
Novel aza-analogues of ganciclovir were obtained from 1,5,5-tris(pivaloyloxymethyl)pyrrolidin-2-one by a one-pot base silylation/nucleoside coupling procedure. The compounds were evaluated for, but found to be devoid of, antiviral activity in vitro.
Keywords
Azanucleosides , N-(Pivaloyloxymethyl)amide , Ganciclovir , Antiviral agents , Pyrrolidinone , Nucleoside analogues
Journal title
Tetrahedron
Serial Year
2007
Journal title
Tetrahedron
Record number
1093325
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