Title of article :
Synthesis of an indole containing KDR kinase inhibitor by tandem Sonogashira coupling-5-endo-dig-cyclization as a key step
Author/Authors :
Sanjay S. Palimkar، نويسنده , , Vijaykumar S. More، نويسنده , , P. Harish Kumar، نويسنده , , Kumar V. Srinivasan، نويسنده ,
Issue Information :
هفته نامه با شماره پیاپی سال 2007
Abstract :
An efficient synthesis of the potent KDR kinase inhibitor 3-[5-[[4-(methylsulfonyl)-1-piperazinyl]methyl]-1H-indol-2-yl]quinoline-2-(1H)-one using a Sonogashira coupling-5-endo-dig-cyclization strategy is described.
Keywords :
KDR kinase inhibitor , 5-endo-dig-Cyclization , Synthesis , Indol-2-yl quinoline-2-one
Journal title :
Tetrahedron
Journal title :
Tetrahedron
