Author/Authors :
Alessandro Piergentili، نويسنده , , Fabio Del Bello، نويسنده , , Francesco Gentili، نويسنده , , Mario Giannella، نويسنده , , Wilma Quaglia، نويسنده , , Cristian Vesprini، نويسنده , , Russell J. Thomas، نويسنده , , Graeme M. Robertson، نويسنده ,
Abstract :
The solution-phase synthesis of the β-turn peptidomimetic ICG-001, a selective inhibitor of Wnt/β-catenin signalling, which has been found to be important for both initiation and progression of cancers of different tissues and has been exploited as an extremely useful chemogenomic tool, was developed. This route is particularly suitable for the multigram scale preparation of ICG-001.
Keywords :
Wnt pathway , Solution-phase synthesis , Peptidomimetic , ICG-001 , Inhibitor
