Title of article
Synthesis and biological evaluation of isoflavone analogues from Dalbergia oliveri
Author/Authors
Sujittra Deesamer، نويسنده , , Udom Kokpol، نويسنده , , Warinthorn Chavasiri، نويسنده , , Soazig Douillard، نويسنده , , Vincent Peyrot، نويسنده , , Nicolas Vidal، نويسنده , , Sébastien Combes، نويسنده , , Jean-Pierre Finet، نويسنده ,
Issue Information
هفته نامه با شماره پیاپی سال 2007
Pages
8
From page
12986
To page
12993
Abstract
Mucronulatol 1 and violanone 2 isolated from Dalbergia oliveri Gamble, and the corresponding isoflavone 3 were prepared by ligand coupling reactions involving organolead reagent. Biological studies have shown a significant cytotoxic effect against an HBL100 leukemia cell line only for isoflavan 1 with an IC50 value amounting to 5.7 μM. All the drugs modestly inhibit the in vitro microtubule assembly, independently of the cytotoxic ability. Natural compounds 1 and 2 have no antibacterial activity, but are potent inhibitors of the Fusarium oxysporum phytopathogenic fungal growth.
Keywords
Ligand coupling , Cytotoxicity , Antimitotic , Isoflavone , Antimicrobial
Journal title
Tetrahedron
Serial Year
2007
Journal title
Tetrahedron
Record number
1093582
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