Title of article :
Design of 1,2-dioxines with anti-Candida activity: aromatic substituted 1,2-dioxines
Author/Authors :
Ian G. Macreadie، نويسنده , , Thomas D. Avery، نويسنده , , Tony V. Robinson، نويسنده , , Peter Macreadie، نويسنده , , Miles Barraclough، نويسنده , , Dennis K. Taylor، نويسنده , , Edward R.T. Tiekink، نويسنده ,
Issue Information :
هفته نامه با شماره پیاپی سال 2008
Abstract :
In an ongoing effort to rationally design new antimicrobials, 47 new 1,2-dioxines have been synthesised. Broad antifungal structure–activity relationships governing aromatically substituted epoxy-1,2-dioxines 2 and 3 and their parent 1,2-dioxines 1 were assessed primarily against the pathogenic yeast, Candida albicans, with haemolytic activity of selected examples also reported.
Keywords :
2-Dioxine , Candida , Epoxy-1 , Haemolytic activity , Antifungal , 2-Dioxine , 1
Journal title :
Tetrahedron
Journal title :
Tetrahedron
