Three-component reaction of 2-alkynylbenzaldehyde, amine, and nucleophile using Lewis acid-surfactant combined catalyst in water

Lewis acid-surfactant combined catalyst (LASC) catalyzed three-component reactions of 2-alkynylbenzaldehyde, amines, and nucleophiles (alkyne, nitromethane, or diethyl phosphate) in water under ultrasonic conditions afforded the corresponding 1,2-dihydroisoquinoline derivatives in good yields.