Title of article :
A convenient microwave-assisted desulfitative dimethylamination of the 2(1H)-pyrazinone scaffold using N,N-dimethylformamide
Author/Authors :
Anuj Sharma، نويسنده , , Vaibhav Pravinchandra Mehta، نويسنده , , Erik Van der Eycken، نويسنده ,
Issue Information :
هفته نامه با شماره پیاپی سال 2008
Abstract :
A convenient microwave-assisted methodology is developed for the generation of 5-chloro-3-(dimethylamino)pyrazin-2(1H)-ones. The method entails a chemoselective desulfitative removal of a phenylthioether bond upon DMF/H2O treatment in the presence of sodium carbonate, yielding the desired compounds in 73–96%.
Keywords :
Microwave-assisted organic synthesis (MAOS) , 2(1H)-Pyrazinone , Dimethylamination , DMF , Desulfitative
Journal title :
Tetrahedron
Journal title :
Tetrahedron
