Author/Authors :
Chiaki Yamauchi، نويسنده , , Masami Kuriyama، نويسنده , , Rumiko Shimazawa، نويسنده , , Tsumoru Morimoto، نويسنده , , Kiyomi Kakiuchi، نويسنده , , Ryuichi Shirai، نويسنده ,
Abstract :
A novel approach for the synthesis of 2,4-dialkyl-3-hydroxybutanolides, having three successive stereogenic centers, by an acid-catalyzed ring-switch reaction of 2-(2-hydroxyalkyl)lactams is described. This transformation was applied to the synthesis of the key intermediates of teromerase inhibitor UCS1025A.
