Title of article
An acid-catalyzed ring-switch reaction of lactams to lactones: concise synthesis of 2,4-dialkyl-3-hydroxybutanolides
Author/Authors
Chiaki Yamauchi، نويسنده , , Masami Kuriyama، نويسنده , , Rumiko Shimazawa، نويسنده , , Tsumoru Morimoto، نويسنده , , Kiyomi Kakiuchi، نويسنده , , Ryuichi Shirai، نويسنده ,
Issue Information
هفته نامه با شماره پیاپی سال 2008
Pages
8
From page
3133
To page
3140
Abstract
A novel approach for the synthesis of 2,4-dialkyl-3-hydroxybutanolides, having three successive stereogenic centers, by an acid-catalyzed ring-switch reaction of 2-(2-hydroxyalkyl)lactams is described. This transformation was applied to the synthesis of the key intermediates of teromerase inhibitor UCS1025A.
Journal title
Tetrahedron
Serial Year
2008
Journal title
Tetrahedron
Record number
1093911
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