Title of article
Anti-inflammatory steroids from the octocoral Dendronephthya griffini
Author/Authors
Chih-Hua Chao، نويسنده , , Zhi-Hong Wen، نويسنده , , I.-Ming Chen، نويسنده , , Jui-Hsin Su، نويسنده , , Ho-Cheng Huang، نويسنده , , Michael Y. Chiang، نويسنده , , Jyh-Horng Sheu، نويسنده ,
Issue Information
هفته نامه با شماره پیاپی سال 2008
Pages
7
From page
3554
To page
3560
Abstract
Five new steroids, griffinisterones A–E (1–5), were isolated from the octocoral Dendronephthya griffini. The structures of these compounds were elucidated by extensive spectroscopic analysis. The single-crystal X-ray crystallography on 1 allowed the determination of the 24R configuration in 1. The absolute stereochemistry of 5 was determined by the application of PGME method. Compounds 3 and 4 were found to significantly inhibit the accumulation of the pro-inflammatory iNOS protein of the LPS-stimulated RAW264.7 macrophage cells.
Keywords
Griffinisterones A–E , Steroid , Anti-inflammatory effect , octocoral
Journal title
Tetrahedron
Serial Year
2008
Journal title
Tetrahedron
Record number
1093960
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