Tetrachlorosilane catalyzed multicomponent one-step fusion of biopertinent pyrimidine heterocycles

Multicomponent one-step fusion of a variety of pharmacologically pertinent pyrimidine heterocycles has efficiently been achieved from their respective aldehydes, β-dicarbonyl compounds, and urea/thiourea in the presence of a catalytic amount of tetrachlorosilane in DMF/AN mixture at normal ambient temperature.