Title of article
Total synthesis of a dienynone from Echinacea pallida
Author/Authors
Stefania Morandi، نويسنده , , Federica Pellati، نويسنده , , Stefania Benvenuti، نويسنده , , Fabio Prati، نويسنده ,
Issue Information
هفته نامه با شماره پیاپی سال 2008
Pages
5
From page
6324
To page
6328
Abstract
The first total synthesis of (8Z,13Z)-pentadeca-8,13-dien-11-yn-2-one is described. This dienynone was recently isolated from the n-hexane extract of Echinacea pallida roots and displayed a selective cytotoxic activity toward cancer cells, thus featuring as a potential anticancer lead. The product was obtained in 11 steps in 25% overall yield.
Keywords
polyenes , Total synthesis , acetylenes , Cytotoxicity , Echinacea pallida
Journal title
Tetrahedron
Serial Year
2008
Journal title
Tetrahedron
Record number
1094261
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